Experiencing overwhelming fear akin to impending death, accompanied by palpitations and difficulty breathing, panic disorder has inflicted psychological distress on many, as its causes and treatments remain unclear. However, recent studies have identified the brain circuits central to panic disorder, offering a crucial discovery that holds promise for developing effective treatment strategies in the future.
Association between the Brain and Panic Disorder
Researchers have revealed the correlation between a specific brain region, the 'lateral parabrachial nucleus,' and symptoms of panic disorder. While the previously assumed association involved the brain region 'amygdala,' known for processing fear, the research team shifted attention to the lateral parabrachial nucleus, noting that patients with amygdala damage still experience panic disorder.
Body Areas Affected by Panic Disorder
The lateral parabrachial nucleus regulates functions such as breathing, heart rate, and body temperature. The research team concluded that this region induces emotional and physiological changes associated with panic disorder. They particularly discovered the production of 'PACAP,' a key regulator of stress response, in the lateral parabrachial nucleus. Animal experiments confirmed the correlation between the activation of specific nerve cells in this region and the expression of PACAP during the onset of panic disorder.
Advancements in Panic Disorder Treatment Research
The discovery of the PACAP brain circuit is considered a significant advancement in completing the map of panic disorder. Previous research focused on studying various brain regions to pinpoint the origin of panic disorder. With the revelation of the brain circuit related to panic disorder, it is expected to contribute to the development of alternative treatments beyond the existing serotonin system-targeting drugs.
Hope for the Future
These research findings offer hope for many individuals suffering from panic disorder. Unraveling the complex causes of panic disorder and establishing precise treatment strategies has been a significant challenge for the medical community and patients alike. Nevertheless, current research presents a crucial step forward in addressing this challenge. Anticipation grows for future research and development, with the prospect of introducing new treatment methods that alleviate the suffering caused by panic disorder.
